Diffusion tensor imaging reveals micro-structural alterations in brain white matter of adult chronic active marijuana users

dc.contributor.author Gonzales, Rachael May K.
dc.date.accessioned 2016-03-09T19:36:40Z
dc.date.available 2016-03-09T19:36:40Z
dc.date.issued 2011-12
dc.description M.S. University of Hawaii at Manoa 2011.
dc.description Includes bibliographical references.
dc.description.abstract Since CB1 receptors are expressed within adult brain white matter (Molina-Holgado, Vela et al. 2002) and influence brain white matter development (Armstrong, Schleicher et al. 1995; Berrendero, Garcia-Gil et al. 1998), we hypothesized that longterm, daily MJ use in adults would result in lower FA and AD and higher Trace and RD in regions that continue to myelinate into adulthood such as the superior longitudinal fasciculus (Sowell, Thompson et al. 1999; Ashtari, Cervellione et al. 2007), temporal white matter (Ashtari, Cervellione et al. 2007), and frontal white matter (Ashtari, Cervellione et al. 2007). Conversely, we did not expect to see alterations in the corpus callosum or internal capsule as these structures complete myelination within the first year of life (Brubaker, Schmithorst et al. 2009). Additionally, we hypothesized that there would be a correlation between microstructural changes and age of MJ initiation.
dc.identifier.uri http://hdl.handle.net/10125/101409
dc.language.iso eng
dc.publisher [Honolulu] : [University of Hawaii at Manoa], [December 2011]
dc.relation Theses for the degree of Master of Science (University of Hawaii at Manoa). Biomedical Sciences.
dc.subject marijuana
dc.title Diffusion tensor imaging reveals micro-structural alterations in brain white matter of adult chronic active marijuana users
dc.type Thesis
dc.type.dcmi Text
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