Diffusion tensor imaging reveals micro-structural alterations in brain white matter of adult chronic active marijuana users

Date
2011-12
Authors
Gonzales, Rachael May K.
Journal Title
Journal ISSN
Volume Title
Publisher
[Honolulu] : [University of Hawaii at Manoa], [December 2011]
Abstract
Since CB1 receptors are expressed within adult brain white matter (Molina-Holgado, Vela et al. 2002) and influence brain white matter development (Armstrong, Schleicher et al. 1995; Berrendero, Garcia-Gil et al. 1998), we hypothesized that longterm, daily MJ use in adults would result in lower FA and AD and higher Trace and RD in regions that continue to myelinate into adulthood such as the superior longitudinal fasciculus (Sowell, Thompson et al. 1999; Ashtari, Cervellione et al. 2007), temporal white matter (Ashtari, Cervellione et al. 2007), and frontal white matter (Ashtari, Cervellione et al. 2007). Conversely, we did not expect to see alterations in the corpus callosum or internal capsule as these structures complete myelination within the first year of life (Brubaker, Schmithorst et al. 2009). Additionally, we hypothesized that there would be a correlation between microstructural changes and age of MJ initiation.
Description
M.S. University of Hawaii at Manoa 2011.
Includes bibliographical references.
Keywords
marijuana
Citation
Rights
Access Rights
Email libraryada-l@lists.hawaii.edu if you need this content in ADA-compliant format.