Creatine phosphokinase elevations following exercise in individuals infected with the human immunodeficiency virus
Date
2005
Authors
Contributor
Advisor
Department
Instructor
Depositor
Speaker
Researcher
Consultant
Interviewer
Narrator
Transcriber
Annotator
Journal Title
Journal ISSN
Volume Title
Publisher
University of Hawaii at Manoa
Volume
Number/Issue
Starting Page
Ending Page
Alternative Title
Abstract
Problem: Muscle disease is a well described consequence of HIV infection and its therapy. While symptomatic myopathy is rare, elevations in serum markers of muscle injury are seen more commonly. These elevations may represent subclinical muscle damage due to human immunodeficiency virus (HIV) infection and/or antiretroviral therapy. Provocative testing of muscle by resistance training may elicit abnormal patterns of the enzyme creatine phosphokinase (CK) in HIV-infected individuals with muscle abnormalities. Methods: Thirteen untrained HIV-infected individuals on antiretroviral therapy and six age- and gender-matched HIV-seronegative controls took part in a single session of isokinetic leg exercise. The degree of CK elevation was assessed at several intervals post-exercise. The magnitude and duration of CK elevation was related to demographic, anthropomorphic, functional and HIV disease-related variables. Results: The HIV-positive participants had lower body fat percentage and body mass index compared to controls, but comparable muscle mass and function. There were no significant differences between the HIV-positive participants and the control group with regard to baseline or peak CK values, nor were there differences in the time to peak CK values or to normalization post-exercise. Conclusion: This feasibility study did not reveal significant variables correlating to CK elevations in those with HIV-disease. Further investigation utilizing a larger sample population may be warranted.
Description
Keywords
HIV-positive persons--Health and hygiene, Exercise--Physiological aspects, Creatine kinase
Citation
Extent
Format
Geographic Location
Time Period
Related To
Theses for the degree of Master of Science (University of Hawaii at Manoa). Biomedical Sciences; no. 4014
Related To (URI)
Table of Contents
Rights
All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Rights Holder
Local Contexts
Collections
Email libraryada-l@lists.hawaii.edu if you need this content in ADA-compliant format.