Steroid hormones and subcellular processes
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1968
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[Honolulu]
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Abstract
Aldosterone administered intraperitoneally induced an increase in the rate of renal RNA synthesis in the rat. A maximum response of 130 percent of control occurred 1.5 hours after injection. Following the maximum at 1.5 hours, the rate of renal RNA synthesis oscillated about control. Three cycles in the rate of kidney RNA synthesis occurred within 4.5 hours after injection with no indication of a decrease in amplitude. Renal RNA synthesis is stimulated to a maximum of 210 percent of control 30 minutes after an intravenous aldosterone injection. Following the maximum at 30 minutes, the rate of kidney RNA synthesis oscillated about control but with longer periods and greater amplitude than when the hormone was given intraperitoneally. Aldosterone induced oscillations in renal RNA synthesis occurred in normal, adrenalectomized and hypophysectomized rats. Aldosterone in doses of 0.07 pg to 2.5 pg was effective in inducing the oscillations. Intravenous administration of cortisol or aldosterone diminished the rate of splenic RNA synthesis in rats. Inhibition to 70 percent of control occurred within four hours after hormone injection. Following the initial inhibition, a rapid increase occurred to approximately 160 percent of control. The maximum occurred at five and six hours for cortisol and aldosterone, respectively. A rapid decrease below control level followed the stimulation. The aldosterone induced oscillations in splenic RNA synthesis was observed in normal, adrenalectomized and hypophysectomized rats. The hormone induced oscillations in renal and splenic RNA synthesis appear to be unrelated. The possibility is suggested that the oscillations are unique functions of the respective tissues and that they are independent of external control.
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Thesis (Ph. D.)--University of Hawaii, 1968.
Bibliography: leaves 91-103.
ix, 103 l graphs, tables
Thesis (Ph. D.)--University of Hawaii, 1968.
Bibliography: leaves 91-103.
ix, 103 l graphs, tables
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Steroid hormones, RNA
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Theses for the degree of Doctor of Philosophy (University of Hawaii (Honolulu)). Biomedical Sciences (Biochemistry); no. 188
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