Control of the Coqui frog, Eleutherodactylus coqui

dc.contributor.advisor Ako, Harry en_US Hutchinson, Robert B. en_US
dc.contributor.department Biomedical Sciences (Physiology) en_US 2009-03-06T19:37:26Z 2009-03-06T19:37:26Z 2003-12 en_US 2003-12 en_US
dc.description vii, 32 leaves en_US
dc.description.abstract Eleutherodactylus coqui is an invasive species whose unchecked population growth is having environmental and social impacts on the Hawaiian islands. One focus was to fine tune doses of possible toxicants to control the frogs. It was found that applied as a spray, a 1% caffeine and 0.01% pyrethrin cocktail yielded complete mortality in a single application. These concentrations could be tested in field trials. Animals treated with the caffeine/pyrethrin cocktail experienced decreases in liver and muscle glycogen and severe hyperglycemia. This is consistent with known phosphodiesterase inhibition triggering enzyme inhibitions that ultimately lead to lethality. IBMX, a caffeine analogue and potent phosphodiesterase inhibitor, when combined with pyrethrin, had a similar effect. Drugs blocking other possible modes of action such as adenosine antagonism and ryanodine receptor opening had no effect. It was therefore suggested that caffeine in combination with pyrethrin might be an effective method for controlling frog populations and the lethality of the treatment may be due to phosphodiesterase inhibition followed by eventual hyperkalemia. en_US
dc.publisher University of Hawaii at Manoa en_US
dc.relation Theses for the degree of Master of Science (University of Hawaii at Manoa). Biomedical Sciences (Physiology); no. 3831 en_US
dc.rights All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner. en_US
dc.rights.uri en_US
dc.title Control of the Coqui frog, Eleutherodactylus coqui en_US
dc.type Thesis en_US
dc.type.dcmi Text en_US
local.identifier.callnumber Q111 .H3 no. 3831 en_US
local.thesis.degreelevel MS en_US