Isolation and Structure Elucidation of New Marine Natural Products Isolated from Hawaiian Invertebrates.

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dc.contributor.authorParrish, Stephen M.
dc.contributor.departmentChemistry
dc.date.accessioned2019-05-28T19:41:07Z
dc.date.available2019-05-28T19:41:07Z
dc.date.issued2017-08
dc.identifier.urihttp://hdl.handle.net/10125/62248
dc.subjectNatural products
dc.subjectBACE1
dc.subjectPolyacetylene
dc.subjectDiterpene
dc.subjectEstrogen
dc.subjectReceptor
dc.subjectSecondary Metabolite
dc.subjectCytotoxicity
dc.subjectBioactivity Guided Isolation
dc.titleIsolation and Structure Elucidation of New Marine Natural Products Isolated from Hawaiian Invertebrates.
dc.typeThesis
dcterms.abstractExtracts of three species of sponge and an egg mass of the nudibranch Hexabranchus sanguineus were examined because they displayed biological activity against either BACE1 or HSV-1 and VSV. In some cases bioactivity guided isolation led to the purified active agent, while in others a loss of activity led to chemical investigations of the extract. The fruits of this labor were identification, characterization, and, in most cases, biological evaluation of 7 new and 10 known compounds from four separate structural classes. The structures of these compounds were elucidated through analyses of NMR experiments(1H, 13C, TOCSY, HMBC, HSQC, COSY, ROESY, and NOESY), HR-MS data, computational simulations, and optical rotations.
dcterms.descriptionPh.D. Thesis. University of Hawaiʻi at Mānoa 2017.
dcterms.languageeng
dcterms.publisherUniversity of Hawaiʻi at Mānoa
dcterms.rightsAll UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
dcterms.typeText

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