Diet-associated epigenetic modulation of phenotypes relevant to autism spectrum disorders

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dc.contributor.advisorMaunakea, Alika K.
dc.contributor.authorAllan, Nina Picher
dc.contributor.departmentCell and Molecular Biology
dc.date.accessioned2024-07-02T23:41:21Z
dc.date.issued2024
dc.description.degreePh.D.
dc.embargo.liftdate2024-12-24
dc.identifier.urihttps://hdl.handle.net/10125/108327
dc.subjectMolecular biology
dc.subjectCellular biology
dc.subjectNeurosciences
dc.subjectautism spectrum disorder
dc.subjectepigenetics
dc.subjectgut microbiome
dc.subjectketogenic diet
dc.subjectmaternal obesity
dc.subjectmiRNA
dc.titleDiet-associated epigenetic modulation of phenotypes relevant to autism spectrum disorders
dc.typeThesis
dcterms.abstractAutism Spectrum Disorder (ASD) is a complex neurodevelopmental condition influenced by genetic and environmental factors. This study explores the role of dietary factors as an environmental influence in ASD pathogenesis and phenotype. Maternal high-fat diet-induced obesity prior to conception, but not during gestation, is associated with ASD-like behavioral symptoms and transcriptomic alterations in offspring. Additionally, adherence to a modified ketogenic diet in children with ASD leads to improvements in behavior and increases in gut microbiome diversity. Mechanistic investigations suggest a potential link between dietary interventions, gut microbiota, and epigenetic modifications, highlighting the dynamic interplay between diet and ASD phenotype. These findings contribute to our understanding of environmental influences on ASD and offer insights for future therapeutic strategies targeting dietary interventions.
dcterms.extent122 pages
dcterms.languageen
dcterms.publisherUniversity of Hawai'i at Manoa
dcterms.rightsAll UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
dcterms.typeText
local.identifier.alturihttp://dissertations.umi.com/hawii:12156

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