Effects of the Perfusion Pressure on the Tolerance of an Isolated Rat Heart to Total Coronary Flow Cessation

Abstract

Using various modifications of the Langendorff technique, it has been fairly well established that an increase in coronary perfusion pressure results in a linear increase in the coronary flow rate; an elevated systolic pressure; a higher oxygen consumption; no appreciable change in heart rate; a slight decline in diastolic pressure; an in the KCl-arrested guinea pig heart, a lengthening of the hyocardial sarcomeres.