Molecular evolution of dengue virus in the Caribbean

dc.contributor.author	Mueller, Brandi
dc.date.accessioned	2011-07-21T23:03:20Z
dc.date.available	2011-07-21T23:03:20Z
dc.date.issued	2008
dc.description.abstract	Dengue is a pantropical mosquito-borne virus infecting SO to 100 million people a year. A group of four closely related serotypes, DENV -1 - 4, cause a wide spectrum of disease, from relatively mild dengue fever (DF) to the more severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). All four serotypes have been expanding geographically, and now circulate hyperendemically in most tropical regions, such as Puerto Rico and the Caribbean. This study addresses the role of virus evolution in changing transmission dynamics in the Caribbean, expanding on initial studies on DENV- 2 and -4 to include DENY -1 and -3 over the same period using the envelope gene.
dc.description.degree	M.S.
dc.identifier.uri	http://hdl.handle.net/10125/20440
dc.language	eng
dc.publisher	University of Hawaii at Manoa
dc.relation	Theses for the degree of Master of Science (University of Hawaii at Manoa). Biomedical Sciences (Tropical Medicine); no. 4324
dc.rights	All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
dc.title	Molecular evolution of dengue virus in the Caribbean
dc.type	Thesis
dc.type.dcmi	Text

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