Effects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites.

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dc.contributor.authorChai, Weiwen
dc.contributor.authorBostick, Roberd M.
dc.contributor.authorAhearn, Thomas U.
dc.contributor.authorFranke, Adrian A.
dc.contributor.authorCuster, Laurie J.
dc.contributor.authorCooney, Robert V.
dc.date.accessioned2013-02-25T22:06:35Z
dc.date.available2013-02-25T22:06:35Z
dc.date.issued2012
dc.description.abstractγ-Tocopherol (γT) protects against DNA-damaging effects of nitrogen oxides, yet its physiologic regulation in vivo is unknown. Observational studies indicate inverse associations of 25[OH]-vitamin D with γT and leptin. To determine whether vitamin D(3) supplementation alters levels of lipid-soluble micronutrients, serum samples (N = 85 subjects) from a randomized, double-blind, placebo-controlled clinical trial of vitamin D(3) (800 IU) and calcium (2 g), alone and in combination, were analyzed for lipid micronutrients and specific vitamin D metabolites at baseline and after 6 mo of supplementation. Serum 25[OH]-vitamin D(3) levels increased 55% (P < 0.0001) and 48% (P = 0.0005), whereas 25[OH]-vitamin D(2) levels were lower by 48% (P = 0.26) and 21% (P = 0.36) in the vitamin D(3) and vitamin D(3) plus calcium groups, respectively. At baseline, γT levels were inversely associated with 25[OH]D (r = -0.31, P = 0.004). With vitamin D(3) plus calcium treatment, serum α-tocopherol decreased 14% (P = 0.04), whereas similar changes in γT (19% lower, P = 0.14) were observed. No significant effects were observed for D(3) supplementation on leptin or retinol levels. These results are consistent with the hypothesis that vitamin D(3) ± calcium affects serum tocopherol and 25[OH]D(2) levels; however, studies using larger, more homogeneous populations are warranted.
dc.identifier.citationChai, Weiwen, Roberd M. Bostick, Thomas U. Ahearn, Adrian A. Franke, Laurie J. Custer and Robert V. Cooney. "Effects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites." Nutrition and Cancer 64, 1 (2012): 57-64. doi: 10.1080/01635581.2012.630552.
dc.identifier.doi10.1080/01635581.2012.630552
dc.identifier.urihttp://hdl.handle.net/10125/26024
dc.languageen-US
dc.relation.ispartof1532-7914
dc.subject.mesh25-Hydroxyvitamin D 2
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCalcifediol
dc.subject.meshCalcium
dc.subject.meshCalcium, Dietary
dc.subject.meshCholecalciferol
dc.subject.meshDietary Supplements
dc.subject.meshDouble-Blind Method
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLeptin
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshTocopherols
dc.subject.meshVitamin A
dc.subject.meshgamma-Tocopherol
dc.titleEffects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites.
dc.typeArticle
dc.type.dcmiText
local.identifier.alturihttp://www.ncbi.nlm.nih.gov/pubmed/22149065

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Cooney, Robert V.