Improving a Gold and Titanium Containing Metallodrug’s Efficacy Against Bladder Cancer

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dc.contributor.advisorRamos, Joe
dc.contributor.advisorBrown, Amy
dc.contributor.authorYata, Lacye
dc.contributor.departmentArt
dc.date.accessioned2023-01-12T00:02:34Z
dc.date.available2023-01-12T00:02:34Z
dc.date.issued2019
dc.description.abstractThe World Health Organization (WHO) names cancer as a leading cause of death worldwide, accounting for 7.6 million deaths (around 13% of all deaths) in 2008 and projected to rise above 13.1 million deaths in 2030 (1). With regard to bladder cancer specifically, 68,000 adults are affected in the United States each year. Although it occurs more frequently in older men than it does in women, bladder cancer can happen at any age. Symptoms may include blood in the urine, painful urination, and pelvic pain. The risk increases with smoking, increase in age, chronic bladder inflammation, family history, and even exposure to certain chemicals (arsenic and chemicals used in dyes, rubber, leather, textiles and paint products) (2). To combat potential complications, a closer look into metallodrugs reveals promising results as an innovational approach to destroying malignant cells. For this study, a metallodrug containing two metals (titanium and gold or ruthenium and gold) with conformational changes within its scaffold will be constructed and tested in this project. Structural variations of the metallodrug will be designed and tested for effectiveness against bladder cancer in vitro. The planned assays will help determine how these metallodrug compounds kill bladder cancer, while providing guidance on ways to improve them. This data will determine what metallodrugs were most effective for follow-up in vivo studies in mouse models.
dc.format.extent28 pages
dc.identifier.urihttps://hdl.handle.net/10125/104385
dc.publisherUniversity of Hawai'i at Manoa
dc.rightsAll UHM Honors Projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
dc.subjectMetallodrugs
dc.subjectcancer
dc.subjectassay
dc.titleImproving a Gold and Titanium Containing Metallodrug’s Efficacy Against Bladder Cancer
dc.type.dcmiText

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