The relationship of 5-aminolevulinic acid on mood and coping ability in prediabetic adults

Gonzales, Rachael May K.
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[Honolulu] : [University of Hawaii at Manoa], [December 2014]
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In the U.S., diabetes affects 25.8 million Americans (CDC 2011). The most effective diabetes prevention method in prediabetic individuals is lifestyle modification (Tabak, Herder et al. 2012). Despite the benefits of lifestyle change, diabetes prevalence continues to increase (CDC 2012). This may be because of the many emotional barriers that a prediabetic individual faces when it comes to starting an exercise routine and a healthy eating plan. A potential treatment for the emotional obstacles that prediabetic adults may face is a natural supplement called 5-aminolevulinic acid (5-ALA). In the current study, the group included 154 participants, both men and women, ranging between the ages of 41 to 71 years old. The study design was a double-blind, randomized parallel-group study. The Psychosocial Depression Symptoms Questionnaire (PDS) and the Perceived Stress Scale (PSS) were used to examine the relationship of two doses of 5-ALA (15mg and 50mg) with mood and coping ability. Using SAS software, an ordered logistic regression model was used to analyze the association between the dose groups (control, 15mg, and 50 mg) and responses to the two questionnaires. An integrative literature review, using the PubMed database, of the relationship between 5-ALA administrations and mood and coping ability was performed. First, our literature review resulted in zero published articles. Second, utilizing the two questionnaires, the intake of 5-ALA was found to be associated with significantly improve self-perception of effort spent (p = 0.002) and coping ability (p = 0.004). Finally, a significant dose-dependent relationship was found for the association of 5-ALA intake on measures of effort (p = 0.003), loneliness (p = 0.006), and coping ability (p = 0.003). The 50mg dose was more effective than the 15mg dose in improving these measures. In conclusion, we report that after 12 weeks of taking 5-ALA, self-perception of effort spent, loneliness, and coping ability were associated with improvements in a group of prediabetic adults. Improved mood and coping ability may enable prediabetic individuals to overcome the emotional obstacles preventing them from maintaining a healthy lifestyle and avoiding the development of diabetes.
Ph.D. University of Hawaii at Manoa 2014.
Includes bibliographical references.
5-ALA, 5-aminolevulinic acid, prediabetes, mood, copying ability
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Theses for the degree of Doctor of Philosophy (University of Hawaii at Manoa). Biomedical Sciences.
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