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Fanconi Anemia Signaling: The Role of FANCD2 During M Phase.

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Title:Fanconi Anemia Signaling: The Role of FANCD2 During M Phase.
Authors:Che, Raymond
Contributors:Molecular Biosciences & Bioeng (department)
Keywords:Fanconi anemia
Date Issued:May 2018
Publisher:University of Hawaiʻi at Mānoa
Abstract:In 1927, Guido Fanconi described a hereditary condition presenting panmyelopathy accompanied by short stature and hyperpigmentation, better known as Fanconi anemia (FA). With this discovery, the genetic and molecular basis underlying FA has emerged as a field of great interest. FA signaling is critical in the DNA damage response (DDR) to mediate the repair of damaged DNA. This has attracted a diverse range of investigators, especially those interested in aging and cancer. However, recent evidence suggests FA signaling also regulates functions outside of the DDR, with implications in many other frontiers of research. The majority of research regarding FA signaling and the cell cycle primarily investigates DNA damage repair and its role during S phase and replicative stress. Here we discuss the relevant roles of FA signaling and FANCD2 during M phase and its particular role in chromosome segregation, along with a novel FANCD2 interacting partner.
Description:M.S. Thesis. University of Hawaiʻi at Mānoa 2018.
Rights:All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Appears in Collections: M.S. - Molecular Biosciences and Bioengineering

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