Plasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control study.

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dc.contributor.authorEpplein, Meira
dc.contributor.authorShvetsov, Yurii B.
dc.contributor.authorWilkens, Lynne R.
dc.contributor.authorFranke, Adrian A.
dc.contributor.authorCooney, Robert V.
dc.contributor.authorLe Marchand, Loïc
dc.contributor.authorHenderson, Brian E.
dc.contributor.authorKolonel, Laurence N.
dc.contributor.authorGoodman, Marc T.
dc.date.accessioned2013-02-25T22:07:16Z
dc.date.available2013-02-25T22:07:16Z
dc.date.issued2009
dc.description.abstractAssessments by the handful of prospective studies of the association of serum antioxidants and breast cancer risk have yielded inconsistent results. This multiethnic nested case-control study sought to examine the association of plasma carotenoids, retinol, and tocopherols with postmenopausal breast cancer risk.
dc.description.abstractFrom the biospecimen subcohort of the Multiethnic Cohort Study, 286 incident postmenopausal breast cancer cases were matched to 535 controls on age, sex, ethnicity, study location (Hawaii or California), smoking status, date/time of collection and hours of fasting. We measured prediagnostic circulating levels of individual carotenoids, retinol, and tocopherols. Conditional logistic regression was used to compute odds ratios and 95% confidence intervals.
dc.description.abstractWomen with breast cancer tended to have lower levels of plasma carotenoids and tocopherols than matched controls, but the differences were not large or statistically significant and the trends were not monotonic. No association was seen with retinol. A sensitivity analysis excluding cases diagnosed within 1 year after blood draw did not alter the findings.
dc.description.abstractThe lack of significant associations in this multiethnic population is consistent with previously observed results from less racially-diverse cohorts and serves as further evidence against a causal link between plasma micronutrient concentrations and postmenopausal breast cancer risk.
dc.identifier.citationEpplein, Meira, Yurii B. Shvetsov, Lynne R. Wilkens, Adrian A. Franke, Robert V. Cooney, Loic Le Marchand, Brian E. Henderson, Laurence N. Kolonel, and Marc T. Goodman. "Plasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control study." Breast cancer research : BCR 11, 4 (2009): R49. doi: 10.1186/bcr2338.
dc.identifier.doi10.1186/bcr2338
dc.identifier.urihttp://hdl.handle.net/10125/26037
dc.languageen-US
dc.relation.ispartof1465-542X
dc.subject.meshAged
dc.subject.meshBreast Neoplasms
dc.subject.meshCarotenoids
dc.subject.meshCase-Control Studies
dc.subject.meshEthnic Groups
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshPostmenopause
dc.subject.meshRisk
dc.subject.meshSmoking
dc.subject.meshTocopherols
dc.subject.meshUnited States
dc.subject.meshVitamin A
dc.titlePlasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control study.
dc.typeArticle
dc.type.dcmiText
local.identifier.alturihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750110/

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