Plasma 25-hydroxyvitamin D and prostate cancer risk: the multiethnic cohort.

dc.contributor.author Park, Song-Yi en_US
dc.contributor.author Cooney, Robert V. en_US
dc.contributor.author Wilkens, Lynne R. en_US
dc.contributor.author Murphy, Suzanne P. en_US
dc.contributor.author Henderson, Brian E. en_US
dc.contributor.author Kolonel, Laurence N. en_US
dc.date.accessioned 2013-02-25T22:07:00Z
dc.date.available 2013-02-25T22:07:00Z
dc.date.issued 2010-03 en_US
dc.description.abstract The purpose of this study was to examine the relationship of plasma 25-hydroxyvitamin D (25(OH)D) concentrations to prostate cancer within a large multiethnic cohort in Hawaii and California using a nested case-control design. The study included 329 incidents of prostate cancer of African American, Native Hawaiian, Japanese, Latino and White ancestry, and 656 controls matched on age, race/ethnicity, date/time of blood collection and fasting status. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI). No association with prostate cancer risk was found in an analysis based on quartiles of 25(OH)D. When clinically defined cutpoints were used, there was no increased risk for the lowest 25(OH)D concentration (OR for <20 versus 30-<50ng/ml=1.10, 95% CI=0.68-1.78), while there was a suggestive increased risk for higher concentrations (OR for 50ng/ml=1.52, 95% CI=0.92-2.51). The findings from this prospective study of men in the Multiethnic Cohort do not support the hypothesis that vitamin D lowers the risk of prostate cancer. Further follow-up is warranted to determine whether the findings are consistent across ethnic groups. en_US
dc.identifier.citation Park, Song-Yi, Robert V. Cooney, Lynne R. Wilkens, Suzanne P. Murphy, Brian E. Henderson, and Laurence N. Kolonel. "Plasma 25-hydroxyvitamin D and prostate cancer risk: the multiethnic cohort." European journal of cancer (Oxford, England : 1990) 46, 5 (2010): 932-6. doi: 10.1016/j.ejca.2009.12.030. en_US
dc.identifier.doi 10.1016/j.ejca.2009.12.030 en_US
dc.identifier.uri http://hdl.handle.net/10125/26032
dc.language en-US en_US
dc.relation.ispartof 1879-0852 en_US
dc.subject.mesh Aged en_US
dc.subject.mesh California en_US
dc.subject.mesh Case-Control Studies en_US
dc.subject.mesh Hawaii en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Male en_US
dc.subject.mesh Middle Aged en_US
dc.subject.mesh Odds Ratio en_US
dc.subject.mesh Prospective Studies en_US
dc.subject.mesh Prostatic Neoplasms en_US
dc.subject.mesh Risk Factors en_US
dc.subject.mesh Vitamin D en_US
dc.title Plasma 25-hydroxyvitamin D and prostate cancer risk: the multiethnic cohort. en_US
dc.type Article en_US
dc.type.dcmi Text en_US
local.identifier.alturi http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834847/ en_US
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