Plasma 25-hydroxyvitamin D and prostate cancer risk: the multiethnic cohort.

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dc.contributor.authorPark, Song-Yi
dc.contributor.authorCooney, Robert V.
dc.contributor.authorWilkens, Lynne R.
dc.contributor.authorMurphy, Suzanne P.
dc.contributor.authorHenderson, Brian E.
dc.contributor.authorKolonel, Laurence N.
dc.date.accessioned2013-02-25T22:07:00Z
dc.date.available2013-02-25T22:07:00Z
dc.date.issued2010-03
dc.description.abstractThe purpose of this study was to examine the relationship of plasma 25-hydroxyvitamin D (25(OH)D) concentrations to prostate cancer within a large multiethnic cohort in Hawaii and California using a nested case-control design. The study included 329 incidents of prostate cancer of African American, Native Hawaiian, Japanese, Latino and White ancestry, and 656 controls matched on age, race/ethnicity, date/time of blood collection and fasting status. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI). No association with prostate cancer risk was found in an analysis based on quartiles of 25(OH)D. When clinically defined cutpoints were used, there was no increased risk for the lowest 25(OH)D concentration (OR for <20 versus 30-<50ng/ml=1.10, 95% CI=0.68-1.78), while there was a suggestive increased risk for higher concentrations (OR for 50ng/ml=1.52, 95% CI=0.92-2.51). The findings from this prospective study of men in the Multiethnic Cohort do not support the hypothesis that vitamin D lowers the risk of prostate cancer. Further follow-up is warranted to determine whether the findings are consistent across ethnic groups.
dc.identifier.citationPark, Song-Yi, Robert V. Cooney, Lynne R. Wilkens, Suzanne P. Murphy, Brian E. Henderson, and Laurence N. Kolonel. "Plasma 25-hydroxyvitamin D and prostate cancer risk: the multiethnic cohort." European journal of cancer (Oxford, England : 1990) 46, 5 (2010): 932-6. doi: 10.1016/j.ejca.2009.12.030.
dc.identifier.doi10.1016/j.ejca.2009.12.030
dc.identifier.urihttp://hdl.handle.net/10125/26032
dc.languageen-US
dc.relation.ispartof1879-0852
dc.subject.meshAged
dc.subject.meshCalifornia
dc.subject.meshCase-Control Studies
dc.subject.meshHawaii
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshOdds Ratio
dc.subject.meshProspective Studies
dc.subject.meshProstatic Neoplasms
dc.subject.meshRisk Factors
dc.subject.meshVitamin D
dc.titlePlasma 25-hydroxyvitamin D and prostate cancer risk: the multiethnic cohort.
dc.typeArticle
dc.type.dcmiText
local.identifier.alturihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834847/

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Cooney, Robert V.
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