Genome-wide association study of colorectal cancer identifies six new susceptibility loci
| dc.contributor.author | Le Marchand, Loic | |
| dc.date.accessioned | 2016-04-29T21:13:24Z | |
| dc.date.available | 2016-04-29T21:13:24Z | |
| dc.date.issued | 2015-07 | |
| dc.description.abstract | <p>Note: A full list of authors and affiliations appears at the end of the article. </p> <p>Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.</p> | |
| dc.format.extent | 7 | |
| dc.identifier.doi | 10.1038/ncomms8138 | |
| dc.identifier.uri | http://hdl.handle.net/10125/40205 | |
| dc.language.iso | en-US | |
| dc.publisher | Nature | |
| dc.relation.uri | http://www.nature.com/ncomms/2015/150707/ncomms8138/full/ncomms8138.html | |
| dc.title | Genome-wide association study of colorectal cancer identifies six new susceptibility loci | |
| dc.type | Article | |
| dc.type.dcmi | Text |