Semantic Computational Models for Polypharmacology: Applications in Drug Repurposing

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dc.contributor.authorJuric, Radmila
dc.contributor.authorAlmami, Eiman
dc.contributor.authorAlmami, Btesam
dc.contributor.authorAhmed, Zaki
dc.date.accessioned2022-12-27T19:06:41Z
dc.date.available2022-12-27T19:06:41Z
dc.date.issued2023-01-03
dc.description.abstractThis paper proposes a computational model based on the first order logic reasoning, for managing discoveries in Polypharmacology for the purpose of efficient drug repositioning. The model uses computational reasoning upon advances documented in the published literature and thus is primarily based on the range of discoveries in biomedical science. The idea behind the model is to exploit drugs multiple intended and particularly unintended therapeutical and adverse targets and discover if they can lead us towards drug repurposing. Computational pharmacology is a very complex field, but reasoning upon its concept can bring us closer to the ideal poly pharmacological world of finding, developing and approving multitargeted drugs and use them in drug repurposing.
dc.format.extent10
dc.identifier.doi10.24251/HICSS.2023.377
dc.identifier.isbn978-0-9981331-6-4
dc.identifier.other61055e71-b3fc-4139-a90a-3b328da35585
dc.identifier.urihttps://hdl.handle.net/10125/103008
dc.language.isoeng
dc.relation.ispartofProceedings of the 56th Hawaii International Conference on System Sciences
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectIT Architectures and Implementations in Healthcare Environments
dc.subjectdrug repurposing
dc.subjectpolypharmacology
dc.subjectreasoning
dc.titleSemantic Computational Models for Polypharmacology: Applications in Drug Repurposing
dc.type.dcmitext
prism.startingpage3075

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