The Effects of C-Reactive Protein and Platelet-Activating Factor in Platelet Aggregation and in Superoxide Anion and Hydrogen Peroxide Formation
The Effects of C-Reactive Protein and Platelet-Activating Factor in Platelet Aggregation and in Superoxide Anion and Hydrogen Peroxide Formation
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2014-01-15
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Iwamoto, Lynn
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Biology
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University of Hawaii at Manoa
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The initial observation was made by Tillet and Francis in 1930 in patients in the acute phase of lobar pneumonia (3). In 1941, Abernethy and Avery designated the term CRP based on its binding to C-polysaccharide via phosphorylcholine residues, in the presence of calcium (4). Many other compounds, including nucleotides, nucieic acids, carbohydrates, and lipids, react with CRP by phosphorylcholine binding (2). Since its first discovery, CRP has been found in several mammals and other vertebrates (2) and at elevated levels during the acute episodes of a variety of diseases.
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iv, 49 pages
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