Grandinetti, Andrew2009-07-152009-07-151994http://hdl.handle.net/10125/9389Thesis (Ph. D.)--University of Hawaii at Manoa, 1994.Includes bibliographical references (leaves 89-106).Microfiche.xi, 106 leaves, bound ill. 29 cmFree radical oxidation may be involved in the etiology of idiopathic Parkinson's disease (IPD).A nested case-control study of the association of IPO with serum and dietary antioxidants was conducted in the Honolulu Heart Program (ID-IP) cohort of 8,006Japanese men. Eighty-four definite IPO cases occurring in the HHP cohort were verified by autopsy, record review, or direct neurological examination, and age-matched with 336 controls. Dietary and serum antioxidant data for this study were obtained from the first HHP cohort examination (Exam I) in 1965-1968. Conditional logistic regression was used to estimate odds ratios (ORs) for each variable, and as a test of trend for ordinal data and continuous data collapsed into quartiles. The adjusted odds ratio (aOR) relating IPO occurrence to vitamin E intake greater than the Recommended Dietary Allowance (RDA)was not significant (aOR=O.64, 95 percent a 0.35-1.17). The test for trend was also not significant. Intakes of several foods with high vitamin E content identified in a 24 hour dietary recall in 196>1968 were inversely associated with IPD occurrence, but only legume consumption was significantly associated (aOR =0.27, 95 percent CI 0.09-0.78). IPD occurrence was, however, associated with vitamin C intake above the RDA (OR =1.74,95 percent a 1.07-2.85). The association was attenuated by adjustment for smoking and coffee drinking (aOR =1.51, 95 percent a 0.90-2.52), and the test for trend was also not significant after adjustment for smoking and coffee drinking. IPD was also inversely associated with consumption of a western diet (aOR =0.6095 percent a 0.35-1.01) when compared with a Japanese diet, but no significant trend was detected after adjustment for smoking and coffee drinking. IPD was also associated with serum. uric acid (VA) concentration (aOR = 0.82, 95 percent a 0.69-0.99). The odds ratio for VA above the median (OR=O.60, 95 percent a 0.37-0.97) was only slightly attenuated after adjustment for smoking history and coffee consumption (aOR = 0.66, 95 percent a 0.41-1.08). IPD may be associated with prior dietary factors, but the relationship may be complex and difficult to measure retrospectively using epidemiologic techniques.en-USAll UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.Parkinson's diseaseAntioxidantsThesis