Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women.
Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women.
dc.contributor.author | Maetani, Micah | |
dc.contributor.author | Maskarinec, Gertraud | |
dc.contributor.author | Franke, Adrian A. | |
dc.contributor.author | Cooney, Robert V. | |
dc.date.accessioned | 2013-02-25T22:07:19Z | |
dc.date.available | 2013-02-25T22:07:19Z | |
dc.date.issued | 2009 | |
dc.description.abstract | Vitamin D deficiency and adipocytokines have been implicated in the etiology of aging-related diseases such as cancer, osteoporosis, and diseases of the cardiovascular system. The association between elevated parathyroid hormone (PTH) and low 25-hydroxyvitamin D (25-OH-VitD) in plasma is used to define vitamin D deficiency, yet their associated mechanistic pathways are unclear. Utilizing plasma samples from women in a previous intervention study, we measured plasma 25-OH-VitD, leptin, adiponectin, PTH, and lipid levels. We observed strong positive associations for leptin with PTH, gamma -tocopherol, and body mass index (BMI) and inverse associations with 25-OH-VitD and adiponectin. Although commonly accepted that vitamin D deficiency causes hyperparathyroidism, we observed this association primarily in individuals with elevated leptin levels, suggesting that leptin may be an important modifier of this effect consistent with 25-OH-VitD-mediated inhibition of leptin. Leptin was highly correlated with the BMI/25-OH-VitD ratio (r = 0.80; P < 0.0001), consistent with a model in which BMI (adiposity) and 25-OH-VitD are the primary determinants of circulating leptin and PTH levels. This model may explain the failure of some studies to observe elevated PTH in vitamin D deficient adolescents and provides important insight into epidemiological studies exploring the associations of these individual biomarkers with chronic disease risk and mortality. | |
dc.identifier.citation | Maetani, M., G. Maskarinec, A. A. Franke, and R. V. Cooney. "Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women." Nutrition and cancer 61, 2 (2009): 225-31. doi: 10.1080/01635580802455149. | |
dc.identifier.doi | 10.1080/01635580802455149 | |
dc.identifier.uri | http://hdl.handle.net/10125/26038 | |
dc.language | en-US | |
dc.relation.ispartof | 1532-7914 | |
dc.subject.mesh | Adiponectin | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Body Mass Index | |
dc.subject.mesh | Carotenoids | |
dc.subject.mesh | Diet | |
dc.subject.mesh | Female | |
dc.subject.mesh | Fruit | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Hyperparathyroidism | |
dc.subject.mesh | Leptin | |
dc.subject.mesh | Lipids | |
dc.subject.mesh | Parathyroid Hormone | |
dc.subject.mesh | Regression Analysis | |
dc.subject.mesh | Risk Factors | |
dc.subject.mesh | Vegetables | |
dc.subject.mesh | Vitamin D | |
dc.subject.mesh | Vitamin D Deficiency | |
dc.title | Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women. | |
dc.type | Article | |
dc.type.dcmi | Text | |
local.identifier.alturi | http://www.ncbi.nlm.nih.gov/pubmed/19235038 |