Association of plasma micronutrient levels and urinary isoprostane with risk of lung cancer: the multiethnic cohort study.

dc.contributor.author Epplein, Meira
dc.contributor.author Franke, Adrian A.
dc.contributor.author Cooney, Robert V.
dc.contributor.author Morris, J. Steven
dc.contributor.author Wilkens, Lynne R.
dc.contributor.author Goodman, Marc T.
dc.contributor.author Murphy, Suzanne P.
dc.contributor.author Henderson, Brian E.
dc.contributor.author Kolonel, Laurence N.
dc.contributor.author Le Marchand, Loïc
dc.date.accessioned 2013-02-25T22:07:10Z
dc.date.available 2013-02-25T22:07:10Z
dc.date.issued 2009-07
dc.description.abstract Although smoking is the primary risk factor for lung cancer, there is evidence to suggest that fruit and vegetable intake are important cofactors. The present case-control study, nested within the Multiethnic Cohort Study, examined the associations of biomarkers of fruit and vegetable intake (individual plasma micronutrient levels), serum selenium, and a urinary biomarker for total lipid peroxidation with lung cancer risk. Two hundred seven incident cases were matched to 414 controls on age, sex, ethnicity, study location (Hawaii or California), smoking status, date/time of collection, and hours of fasting. We measured prediagnositic circulating levels of individual tocopherols and carotenoids, retinol, and serum selenium, and urinary 15-isoprostane F(2t). Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI). For men, strong reductions in risk were seen with increasing tertiles of each plasma carotenoid, with the ORs for the third tertile, compared with the first tertile, ranging from 0.24 to 0.45 (P(trends), 0.002-0.04). No associations were found among women for carotenoids or among either sex for tocopherols, selenium, and retinol. A doubling in risk was seen for men in the second and third tertiles, compared with the first tertile of urinary 15-isoprostane F(2t) (OR, 2.31; 95% CI, 1.02-5.25; and OR, 2.16; 95% CI, 0.98-4.78). This study supports the previously observed association between circulating carotenoids and lung cancer risk in men, and adds to the limited literature regarding urinary 15-isoprostane F(2t) as a marker of cancer risk. Future research examining the possible relationship between isoprostanes and lung cancer is warranted.
dc.identifier.citation Epplein, Meira, Adrian A. Franke, Robert V. Cooney, J. Steven Morris, Lynne R. Wilkens, Marc T. Goodman, Suzanne P. Murphy, Brian E. Henderson, Laurence N. Kolonel, and Loïc Le Marchand. "Association of plasma micronutrient levels and urinary isoprostane with risk of lung cancer: the multiethnic cohort study." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 18, 7 (2009): 1962-70. doi: 10.1158/1055-9965.EPI-09-0003.
dc.identifier.doi 10.1158/1055-9965.EPI-09-0003
dc.identifier.uri http://hdl.handle.net/10125/26035
dc.language en-US
dc.relation.ispartof 1538-7755
dc.subject.mesh Aged
dc.subject.mesh Antioxidants
dc.subject.mesh Biological Markers
dc.subject.mesh California
dc.subject.mesh Carotenoids
dc.subject.mesh Case-Control Studies
dc.subject.mesh Cohort Studies
dc.subject.mesh Diet
dc.subject.mesh Ethnic Groups
dc.subject.mesh F2-Isoprostanes
dc.subject.mesh Female
dc.subject.mesh Fruit
dc.subject.mesh Hawaii
dc.subject.mesh Humans
dc.subject.mesh Lung Neoplasms
dc.subject.mesh Male
dc.subject.mesh Micronutrients
dc.subject.mesh Middle Aged
dc.subject.mesh Risk
dc.subject.mesh Selenium
dc.subject.mesh Tocopherols
dc.subject.mesh Vegetables
dc.title Association of plasma micronutrient levels and urinary isoprostane with risk of lung cancer: the multiethnic cohort study.
dc.type Article
dc.type.dcmi Text
local.identifier.alturi http://www.ncbi.nlm.nih.gov/pubmed/19531680
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
nihms-141515.pdf
Size:
319.34 KB
Format:
Adobe Portable Document Format
Description: