The Effect Of Chloroquine And Pyrimethamine On The Growth Of Two Strains Of The Human Malaria Parasite, Plasmodium Falciparum, After Long-Term Continuous In Vitro Cultivation
Date
2014-01-15
Authors
Contributor
Advisor
Department
Instructor
Depositor
Speaker
Researcher
Consultant
Interviewer
Narrator
Transcriber
Annotator
Journal Title
Journal ISSN
Volume Title
Publisher
University of Hawaii at Manoa
Volume
Number/Issue
Starting Page
Ending Page
Alternative Title
Abstract
Two strains of the human malaria parasite, Plasmodium falciparum, were maintained in Aotus trivirgatus by serial passages, subsequently cultured continuously·in-vitro, and then tested to determine their susceptibility to two antimalarial drugs, chloroquine and pyrimethamine. The Uganda-Palo Alto (FUP) strain, susceptible to chloroquine and resistant to pyrimethamine when maintained in-vivo, was found to be more susceptible to chloroquine and susceptible to pyrimethamine after continuous in-vitro cultivation for 652 days. The Vietnam-Oak Knoll (FVO) strain, resistant to chloroquine and susceptible to pyrimethamine when maintained in-vivo, was found to be susceptible to chloroquine and more susceptible to pyrimethamine after continuous in-vitro cultivation for 297 days. It was also found that after continuous in-vitro cultivation, the FUP and FVO strains showed similar sensitivities to comparable concentrations of both chloroquine and pyrimethamine, whereas prior to long term in-vitro cultivation, their responses to these two drugs were distinct.
Description
Keywords
Citation
Extent
24 pages
Format
Geographic Location
Time Period
Related To
Related To (URI)
Table of Contents
Rights
All UHM Honors Projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Rights Holder
Local Contexts
Collections
Email libraryada-l@lists.hawaii.edu if you need this content in ADA-compliant format.