Wearable Biosensors to Evaluate Recurrent Opioid Toxicity After Naloxone Administration: A Hilbert Transform Approach

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dc.contributor.authorChintha, Keerthi Kumar
dc.contributor.authorIndic, Premananda
dc.contributor.authorChapman, Brittany
dc.contributor.authorBoyer, Edward W
dc.contributor.authorCarreiro, Stephanie
dc.date.accessioned2017-12-28T01:49:30Z
dc.date.available2017-12-28T01:49:30Z
dc.date.issued2018-01-03
dc.description.abstractOpioid abuse is a rapidly escalating problem in the United States. Effective opioid reversal is achieved with the antidote naloxone, but often does not last as long as the offending opioid, necessitating in-hospital observation. Continuous physiologic monitoring using wearable biosensors represents a potential option to extend monitoring capability outside the clinical setting across the spectrum of opioid abuse including post- naloxone administration. The present study aims to identify the physiologic change that marks the cessation of naloxone’s effect. Eleven participants were recruited in the Emergency Department after naloxone administration for an opioid overdose and continuously monitored using a wearable biosensor measuring heart rate, temperature, electrodermal activity and accelerometry. Hilbert transform was used to evaluate a 90- minute post naloxone time point. Physiologic changes were consistent with the onset of opioid drug effect across parameters, but only changes in heart rate and skin temperature research statistical significance.
dc.format.extent6 pages
dc.identifier.doi10.24251/HICSS.2018.410
dc.identifier.isbn978-0-9981331-1-9
dc.identifier.urihttp://hdl.handle.net/10125/50298
dc.language.isoeng
dc.relation.ispartofProceedings of the 51st Hawaii International Conference on System Sciences
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectReal-World Evaluation of Biosensor-Based Interventions in Healthcare
dc.subjectwearables, biosensors, opioids
dc.titleWearable Biosensors to Evaluate Recurrent Opioid Toxicity After Naloxone Administration: A Hilbert Transform Approach
dc.typeConference Paper
dc.type.dcmiText

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