Systemic mitochondrial function, type 2 diabetes, obesity, and life-style modifications

Abstract

Mitochondrial (mt) dysfunction is emerging as a key factor of T2DM. We hypothesize that systemic mt function in PBMCs is altered in the presence of T2DM and obesity, and can be improved with life-style modifications, regardless of T2DM and obesity status. In a cross-sectional study (N = 84), PBMC mtDNA levels and OXPHOS Complex I protein levels are increased in the presence of obesity and decreased in the presence of T2DM. Mt parameters correlated with clinical and metabolic measurements. In a longitudinal study, systemic mt function is increased in PBMCs due to life-style modifications, regardless of T2DM status. Findings in our investigations show that systemic mt function in PBMCs is altered in the presence of T2DM and/or obesity and can be improved with life-style modifications. Our study suggests that altered mt function in PBMCs is associated with T2DM and obesity, and can be improved through life-style modifications.