Cyclic AMP Metabolism In Cardiac Tissue Of Spontaneously Hypertensive Rats: Adenyl Cyclase Activity

dc.contributor.advisor Ramanathan, S. en_US
dc.contributor.author Taasaki, Thomas en_US
dc.contributor.department Biology en_US
dc.date.accessioned 2014-01-15T20:09:28Z
dc.date.available 2014-01-15T20:09:28Z
dc.date.issued 2014-01-15 en_US
dc.description.abstract Cyclic AMP was discovered in 1956 by Rall, Berthet, and Sutherland, who had been studying the stimulation of glycogenolysis by glucagon and epinephrine. A heat-stable factor was found to mediate the action of these hormones on the activation of liver phosphorylase (Figure 1). The factor increased the rate at which phosphorylase b (inactive) was converted to phosphorylase a (active) by stimulation of dephosphophosphorylase kinase (37). Later identified as adenosine 3',5'-monophosphate or cyclic AMP (23, 24), this factor was also found to inhibit the formation of glycogen by its action on a synthetase kinase (37). Thus it was shown that in the liver, glucagon and epinephrine stimulate glycogenolysis via cyclic AMP; the nucleotide simultaneously increases the rate of glycogen breakdown and slows the rate of glycogen formation. en_US
dc.format.extent 60 pages en_US
dc.identifier.uri http://hdl.handle.net/10125/32054
dc.publisher University of Hawaii at Manoa en_US
dc.rights All UHM Honors Projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner. en_US
dc.title Cyclic AMP Metabolism In Cardiac Tissue Of Spontaneously Hypertensive Rats: Adenyl Cyclase Activity en_US
dc.type Term Project en_US
dc.type.dcmi Text en_US
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