Please use this identifier to cite or link to this item:
Investigating the role autoantibodies play among Native Hawaiians and other Pacific Islanders in increased severity of COVID-19
|Title:||Investigating the role autoantibodies play among Native Hawaiians and other Pacific Islanders in increased severity of COVID-19|
|Contributors:||Ching, Lauren (advisor)|
Tseng, Alanna (advisor)
Chang, Sandra (advisor)
Nerurkar, Vivek (instructor)
Sy, Angela (instructor)
show 1 more
|Date Issued:||13 Aug 2021|
|Abstract:||Background: In Hawaii, the Native Hawaiian and other Pacific Islander (NHPI) communities have reported the highest rates of COVID-19. NHPI populations experience higher rates of autoimmune diseases such as type 1 diabetes, systemic lupus erythematosus, and rheumatoid arthritis, which are linked to increased production of autoantibodies, antibodies that target self-antigens and interfere with the typical immune response. Further, increased autoantibody production has been associated with increased disease severity in COVID-19.
Objective: To investigate the relationship between autoantibodies and SARS-CoV-2 infection among NHPI
Hypothesis: NHPI have an increased tendency to produce autoantibodies upon SARS-CoV-2 infection due to their greater predisposition to develop autoimmunity as compared to non-NHPI.
Methods: Using Luminex-based assay, we evaluated a panel of 20 autoantibodies associated with autoimmune diseases in 152 blood samples collected from naturally infected (NI) and/or vaccinated (VX) NHPI (n=58) and non-NHPI (n=94), and negative controls (NEG), (n=14).
Results: Several autoantibodies were detected in subjects who were NI with SARS-CoV-2. There were no differences in the autoantibody levels between NHPI and non-NHPI. Interestingly, SARS-CoV-2 naive VX individuals, both NHPI and non-NHPI, had a reduced tendency to produce autoantibodies, and this was even lower than control subjects (NEG).
Conclusions: The data did not support our initial hypothesis that NHPI produced higher levels of autoantibodies compared to non-NHPI after COVID-19 infection. However, the reduced levels of autoantibodies detected in both NHPI and non-NHPI vaccinated individuals against COVID-19 suggest that vaccination dampens the production of autoantibodies. Individuals who have been previously infected with SARS-CoV-2, however, do not see these same benefits after subsequent vaccination. Natural infection with SARS-COV-2 appears to increase autoantibody production in all ethnicities. Therefore, NHPI, who are predisposed to developing autoimmune diseases, pose an even greater benefit from COVID-19 vaccination.
|Rights:||Attribution-NoDerivs 3.0 United States|
|Appears in Collections:||
MHRT Poster Session 2021|
Please email firstname.lastname@example.org if you need this content in ADA-compliant format.
This item is licensed under a Creative Commons License