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Lower Body Muscle Function in Frail and Non-Frail People Living with HIV: A Pilot Study
|Title:||Lower Body Muscle Function in Frail and Non-Frail People Living with HIV: A Pilot Study|
|Contributors:||Kimura, Iris (advisor)|
Human Immunodeficiency Virus
Lower Body Function
|Publisher:||University of Hawai'i at Manoa|
|Abstract:||Age-related accelerated physical declines occur in people living with HIV (PLWH) a decade earlier than HIV-uninfected (HIV-) individuals resulting in complications that lead to physical dysfunction and loss of independence. Fried’s Frailty Phenotype (FFP) is a common frailty assessment used to assess these multidimensional complications in PLWH, however lacks sufficient lower body muscle function measurements. The purpose of this study was to objectively assess lower body muscle function (LBMF) in FFP groups using the 30-second chair stand test (30CST) and the Manual Muscle Testing (MMT). Forty PLWH ≥50 years on antiretroviral therapy (ART), categorized into frailty groups (non-frail, pre-frail, frail), were assessed for and lower leg extension (LLE) strength. Average age was 60 (interquartile: 57-66), 95% were male, and 67.5% Caucasian. Both TLBF and body fat (BF) discriminated between (p<0.05) and among (p<0.01) frailty groups. LLE strength showed no differences between groups. Total lean body mass (LBM) and fat free mass (FFM) only discriminated between (p<0.05) non-frail and combined frailty groups (pre-frail + frail). BF significantly correlated (p<0.05) with pre-frail TLBF and frail LLE strength groups while lean LBM significantly correlated (p<0.05) only with pre-frail LLE strength. To our knowledge, this is the first study to assess 30 CST, MMT, and body composition in the presence of frailty in PLWH. Our findings indicate that 30 CST and body composition are measures that can be utilized in identifying declines in lower body muscle function in frail PLWH.|
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Ed.D. - Education|
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