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The Relationships between Atrial Fibrillation and Controversial AF Risk Factors
File under embargo until 2021-10-04
|Title:||The Relationships between Atrial Fibrillation and Controversial AF Risk Factors|
|Contributors:||Grandinetti, Andrew (advisor)|
Public Health (department)
|Publisher:||University of Hawai'i at Manoa|
|Abstract:||Atrial fibrillation (AF) is the most common type of cardiac arrhythmia, which is an important risk factor for stroke—especially in the elderly. The irregular heartbeat of AF causes blood congestion and can lead to the development of blood clots, which may flow to the brain, thereby triggering a fatal stroke. Stroke is an increasing public health concern in the U.S. because it is contributing to rising morbidity and health care costs. Therefore, it is important to prevent AF incidence. Current epidemiological studies in Western countries have identified several risk factors for AF such as aging, hypertension, hyperlipidemia, type-2 diabetes, cardiac disease, obesity, heavy alcohol intake, intensive physical activity, and sleep apnea. This dissertation used data from the Honolulu Asia Aging Study, formerly known as the Honolulu Heart Program, to look at the relationships between AF and controversial AF risk factors within the local Japanese-American population. This dissertation is divided into three main studies. The first study estimated the association between AF and hyperlipidemia. Risk estimates were calculated by lipid measurements of high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), and total cholesterol (TC). The second study used overnight polysomnography (PSG) to estimate the association between AF and sleep apnea in Japanese-Americans in Hawaii. Finally, the third study estimated and compared the association between AF and sleep apnea among local Japanese-American men in Hawaii and Caucasian-American men on the continental U.S. All three studies controlled for confounders such as aging, hypertension, type-2 diabetes, cardiac disease, and smoking. These three studies will hopefully provide new evidence of AF risk factors and contribute to improving preventive techniques.|
|Appears in Collections:||
Ph.D - Public Health|
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