Please use this identifier to cite or link to this item: http://hdl.handle.net/10125/62248

Isolation and Structure Elucidation of New Marine Natural Products Isolated from Hawaiian Invertebrates.

File Size Format  
2017-08-phd-parrish.pdf 5.5 MB Adobe PDF View/Open

Item Summary

Title:Isolation and Structure Elucidation of New Marine Natural Products Isolated from Hawaiian Invertebrates.
Authors:Parrish, Stephen M.
Contributors:Chemistry (department)
Keywords:Natural products
BACE1
Polyacetylene
Diterpene
Estrogen
show 4 moreReceptor
Secondary Metabolite
Cytotoxicity
Bioactivity Guided Isolation
show less
Date Issued:Aug 2017
Publisher:University of Hawaiʻi at Mānoa
Abstract:Extracts of three species of sponge and an egg mass of the nudibranch Hexabranchus sanguineus were examined because they displayed biological activity against either BACE1 or HSV-1 and VSV. In some cases bioactivity guided isolation led to the purified active agent, while in others a loss of activity led to chemical investigations of the extract. The fruits of this labor were identification, characterization, and, in most cases, biological evaluation of 7 new and 10 known compounds from four separate structural classes. The structures of these compounds were elucidated through analyses of NMR experiments(1H, 13C, TOCSY, HMBC, HSQC, COSY, ROESY, and NOESY), HR-MS data, computational simulations, and optical rotations.
Description:Ph.D. Thesis. University of Hawaiʻi at Mānoa 2017.
URI:http://hdl.handle.net/10125/62248
Rights:All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Appears in Collections: Ph.D. - Chemistry


Please email libraryada-l@lists.hawaii.edu if you need this content in ADA-compliant format.

Items in ScholarSpace are protected by copyright, with all rights reserved, unless otherwise indicated.