Please use this identifier to cite or link to this item:
Family History of Substance Use Problems on Cortical Morphometry in Healthy Children
|2015-08-ms-lee_r.pdf||Version for non-UH users. Copying/Printing is not permitted||729.54 kB||Adobe PDF||View/Open|
|2015-08-ms-lee_uh.pdf||For UH users only||739.88 kB||Adobe PDF||View/Open|
|Title:||Family History of Substance Use Problems on Cortical Morphometry in Healthy Children|
|Keywords:||Substance Use Problems|
|Date Issued:||Aug 2015|
|Publisher:||[Honolulu] : [University of Hawaii at Manoa], [August 2015]|
Common structural brain abnormalities reported in substance use related (SUD) related regions were found in children with family history (FH) of SUD. However, the effect of FH-degree of SUD is not well examined. Therefore, the influence of degree of FH of substance use problems (SUP) on cortical morphometry was investigated.
921 typically developing children (ages 3-20 years old; 470 boys/451 girls) had structural MRI and executive functions measures. The influence of first and/or second-degree FH (Any-FH) and the separate effects of first-degree (First-FH) and second-degree FH of SUP (Second-FH) on cortical structures were investigated using FreeSurfer. The relationships between FH related cortical alterations and executive functioning were examined. Sex interactions with FH-degree on cortical morphometry were also investigated.
Any-FH children had volume alterations mediated by changes in surface areas. FH children have larger left prefrontal and right superior areas and volumes when compared to No-FH children. First-FH and Second-FH show a variable effect on cortical volumes particularly for regions in the posterior frontal and anterior parietal regions as well as the right fusiform gyrus. Sex differences for cortical morphometry between First-FH and Second-FH children were widespread, but strongest in the left frontal regions. The left supramarginal and right fusiform gyri, regions specifically reduced for First-FH children, were also related to differential executive functioning and this same association was found in First-FH girls. Importantly, the majority of results remained even when controlling for confounders such as ADHD.
The children with FH of SUP have overall differences in prefrontal regions. First-FH and Second-FH children showed different morphometric alterations in parietal and temporal regions, which may contribute to deficits in executive function. Further studies are need to explore the sex-specific influences in cortical morphometry of children with FH of SUP, and the possible consequences on cognition.
|Description:||M.S. University of Hawaii at Manoa 2015.|
Includes bibliographical references.
|Appears in Collections:||
M.S. - Biomedical Sciences|
Please email email@example.com if you need this content in ADA-compliant format.
Items in ScholarSpace are protected by copyright, with all rights reserved, unless otherwise indicated.