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Family History of Substance Use Problems on Cortical Morphometry in Healthy Children

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Item Summary

Title:Family History of Substance Use Problems on Cortical Morphometry in Healthy Children
Authors:Lee, Kristin
Keywords:Substance Use Problems
Family History
Date Issued:Aug 2015
Publisher:[Honolulu] : [University of Hawaii at Manoa], [August 2015]
Common structural brain abnormalities reported in substance use related (SUD) related regions were found in children with family history (FH) of SUD. However, the effect of FH-degree of SUD is not well examined. Therefore, the influence of degree of FH of substance use problems (SUP) on cortical morphometry was investigated.
921 typically developing children (ages 3-20 years old; 470 boys/451 girls) had structural MRI and executive functions measures. The influence of first and/or second-degree FH (Any-FH) and the separate effects of first-degree (First-FH) and second-degree FH of SUP (Second-FH) on cortical structures were investigated using FreeSurfer. The relationships between FH related cortical alterations and executive functioning were examined. Sex interactions with FH-degree on cortical morphometry were also investigated.
Any-FH children had volume alterations mediated by changes in surface areas. FH children have larger left prefrontal and right superior areas and volumes when compared to No-FH children. First-FH and Second-FH show a variable effect on cortical volumes particularly for regions in the posterior frontal and anterior parietal regions as well as the right fusiform gyrus. Sex differences for cortical morphometry between First-FH and Second-FH children were widespread, but strongest in the left frontal regions. The left supramarginal and right fusiform gyri, regions specifically reduced for First-FH children, were also related to differential executive functioning and this same association was found in First-FH girls. Importantly, the majority of results remained even when controlling for confounders such as ADHD.
The children with FH of SUP have overall differences in prefrontal regions. First-FH and Second-FH children showed different morphometric alterations in parietal and temporal regions, which may contribute to deficits in executive function. Further studies are need to explore the sex-specific influences in cortical morphometry of children with FH of SUP, and the possible consequences on cognition.
Description:M.S. University of Hawaii at Manoa 2015.
Includes bibliographical references.
Appears in Collections: M.S. - Biomedical Sciences

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