Please use this identifier to cite or link to this item: http://hdl.handle.net/10125/50298

Wearable Biosensors to Evaluate Recurrent Opioid Toxicity After Naloxone Administration: A Hilbert Transform Approach

File SizeFormat 
paper0411.pdf988.97 kBAdobe PDFView/Open

Item Summary

Title: Wearable Biosensors to Evaluate Recurrent Opioid Toxicity After Naloxone Administration: A Hilbert Transform Approach
Authors: Chintha, Keerthi Kumar
Indic, Premananda
Chapman, Brittany
Boyer, Edward W
Carreiro, Stephanie
Keywords: Real-World Evaluation of Biosensor-Based Interventions in Healthcare
wearables, biosensors, opioids
Issue Date: 03 Jan 2018
Abstract: Opioid abuse is a rapidly escalating problem in the United States. Effective opioid reversal is achieved with the antidote naloxone, but often does not last as long as the offending opioid, necessitating in-hospital observation. Continuous physiologic monitoring using wearable biosensors represents a potential option to extend monitoring capability outside the clinical setting across the spectrum of opioid abuse including post- naloxone administration. The present study aims to identify the physiologic change that marks the cessation of naloxone’s effect. Eleven participants were recruited in the Emergency Department after naloxone administration for an opioid overdose and continuously monitored using a wearable biosensor measuring heart rate, temperature, electrodermal activity and accelerometry. Hilbert transform was used to evaluate a 90- minute post naloxone time point. Physiologic changes were consistent with the onset of opioid drug effect across parameters, but only changes in heart rate and skin temperature research statistical significance.
Pages/Duration: 6 pages
URI/DOI: http://hdl.handle.net/10125/50298
ISBN: 978-0-9981331-1-9
DOI: 10.24251/HICSS.2018.410
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:Real-World Evaluation of Biosensor-Based Interventions in Healthcare


Please contact sspace@hawaii.edu if you need this content in an ADA compliant alternative format.

Items in ScholarSpace are protected by copyright, with all rights reserved, unless otherwise indicated.