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Association of the DYX1C1 Gene with Chinese Literacy in a Healthy Chinese Population

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Title: Association of the DYX1C1 Gene with Chinese Literacy in a Healthy Chinese Population
Authors: Waye, Mary Miu Yee
Siu, Cynthia O
McBride, Catherine
Ho, Connie Suk-han
Wong, Cheuk Wa
Keywords: Big Data on Healthcare Application
Chinese Literacy, Copy number variation (CNV), DYX1C1 gene, Developmental Dyslexia, LogR ratio
Issue Date: 03 Jan 2018
Abstract: DYX1C1, the first dyslexia candidate gene, has been associated with developmental dyslexia in different populations, but its influence on reading abilities in the general population is less well known. Copy number variants (CNVs) have been implicated in neurodevelopmental and childhood-onset disorders involving cognitive development in previous studies. In this report, we investigated the extent to which genomic CNVs for the SNP previously linked to dyslexia, -3G/A (rs3743205) in the gene DYX1C1, contribute to Chinese and English literacy in the general population in a Chinese cohort, and whether these processes, in turn, are influenced by environmental factors, such as family income, parents’ education, and IQ. Our findings suggest that the logR ratio (which is a way to detect CNVs) of a previously reported dyslexia-related SNP, -3G/A (rs3743205) is significantly associated with Chinese literacy in a cohort of Chinese children with normal reading abilities.
Pages/Duration: 10 pages
ISBN: 978-0-9981331-1-9
DOI: 10.24251/HICSS.2018.355
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:Big-Data on Healthcare Application

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