Please use this identifier to cite or link to this item:

Association of the DYX1C1 Gene with Chinese Literacy in a Healthy Chinese Population

File Size Format  
paper0356.pdf 782.05 kB Adobe PDF View/Open

Item Summary

Title:Association of the DYX1C1 Gene with Chinese Literacy in a Healthy Chinese Population
Authors:Waye, Mary Miu Yee
Siu, Cynthia O
McBride, Catherine
Ho, Connie Suk-han
Wong, Cheuk Wa
Keywords:Big Data on Healthcare Application
Chinese Literacy, Copy number variation (CNV), DYX1C1 gene, Developmental Dyslexia, LogR ratio
Date Issued:03 Jan 2018
Abstract:DYX1C1, the first dyslexia candidate gene, has been associated with developmental dyslexia in different populations, but its influence on reading abilities in the general population is less well known. Copy number variants (CNVs) have been implicated in neurodevelopmental and childhood-onset disorders involving cognitive development in previous studies. In this report, we investigated the extent to which genomic CNVs for the SNP previously linked to dyslexia, -3G/A (rs3743205) in the gene DYX1C1, contribute to Chinese and English literacy in the general population in a Chinese cohort, and whether these processes, in turn, are influenced by environmental factors, such as family income, parents’ education, and IQ. Our findings suggest that the logR ratio (which is a way to detect CNVs) of a previously reported dyslexia-related SNP, -3G/A (rs3743205) is significantly associated with Chinese literacy in a cohort of Chinese children with normal reading abilities.
Pages/Duration:10 pages
Rights:Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections: Big-Data on Healthcare Application

Please email if you need this content in ADA-compliant format.

This item is licensed under a Creative Commons License Creative Commons