Genome-wide association study of colorectal cancer identifies six new susceptibility loci
|Title:||Genome-wide association study of colorectal cancer identifies six new susceptibility loci|
|Authors:||Le Marchand, Loic|
|Date Issued:||Jul 2015|
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Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
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University of Hawaii Cancer Center / Cancer Research Center Faculty & Researcher Works|
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