Genome-wide association study of colorectal cancer identifies six new susceptibility loci
|Title:||Genome-wide association study of colorectal cancer identifies six new susceptibility loci|
|Authors:||Le Marchand, Loic|
|Issue Date:||Jul 2015|
Note: A full list of authors and affiliations appears at the end of the article.
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
|Appears in Collections:||University of Hawaii Cancer Center / Cancer Research Center Faculty & Researcher Works|
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