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Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

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Title: Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A
Authors: Wang, Hansong
Burnett, Terrilea
Kono, Suminori
Haiman, Christopher A.
Iwasaki, Motoki
show 33 moreWilkens, Lynne R.
Loo, Lenora W.M.
Van Den Berg, David
Kolonel, Laurence N.
Henderson, Brian E.
Keku, Temitope O.
Sandler, Robert S.
Signorello, Lisa B.
Blot, William J.
Newcomb, Polly A.
Pande, Mala
Amos, Christopher I.
West, Dee W.
Bézieau, Stéphane
Berndt, Sonja I.
Zanke, Brent W.
Hsu, Li
Genetic and Epidemiology of Colorectal Cancer Consortium (GECCO)
Lindor, Noralane M.
Haile, Robert W.
Hopper, John L.
Jenkins, Mark A.
Gallinger, Steven
Casey, Graham
Colon Cancer Family Registry (CCFR)
Stenzel, Stephanie L.
Schumacher, Fredrick R.
Peters, Ulrike
Gruber, Stephen B.
Colorectal Transdisciplinary Study (CORECT)
Tsugane, Shoichiro
Stram, Daniel O.
Le Marchand, Loic

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Issue Date: Aug 2014
Publisher: Nature Communications
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Abstract: The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 x 10^-8) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P = 1.4 x 10^-9), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.
DOI: 10.1038/ncomms5613
Appears in Collections:University of Hawaii Cancer Center / Cancer Research Center Faculty & Researcher Works

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