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Research Leading to the Establishment of a Serum Neuroletpic Assay in Hawaii

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Title:Research Leading to the Establishment of a Serum Neuroletpic Assay in Hawaii
Authors:Morton, Bruce
Contributors:Chemistry (department)
Date Issued:15 Jan 2014
Publisher:University of Hawaii at Manoa
Abstract:The research carried out in this laboratory was primarily based on a clinical observation that the therapeutic effect correlated well ldth the serum neuroleptic level, rather than the neuroleptic dosage administered. In this thesis I will described an inexpensive, but sensitive Radioreceptor Assay for measuring neuroleptic levels. The principles behind the assay are similar to the Radioimmuno Assay and involve a nonradioactive (cold) ligand competing for the same binding site, i.e. a dopamine receptor, with a radioactive (hot) ligand bound to the binding site. At a constant level of the hot ligand, the cold ligand displaces the hot in order of its concentrations.
Pages/Duration:vii, 78 pages
Rights:All UHM Honors Projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Appears in Collections: Honors Projects for Chemistry

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