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The Effect of 2-Thiophenecarboxylic Acid On Pituitary Growth Hormone Secretion
|Title:||The Effect of 2-Thiophenecarboxylic Acid On Pituitary Growth Hormone Secretion|
|Issue Date:||15 Jan 2014|
|Publisher:||University of Hawaii at Manoa|
|Abstract:||Studies on the effects of 2-thiophenecarboxylic acid (2-TCA) on growth hormone (GH) release and tissue cyclic-AMP concentrations in vitro were carried out. 2-TCA was found to have a variable effect on GH release and cyclic-AMP levels at 7. 2X1o-6M. 2-TCA increased release of GH at 7. 2X10-6M concentrations and to increase pituitary cyclic-AMP concentrations. Decreasing effects were found with increasing amounts of 2-TCA. Furthermore, doses of 2-TCA that failed to stimulate hormone release also failed to increase tissue cyclic-AMP levels. Dibutyryl cyclic 3', 5'-adeno sine rnonophosphate and cholera toxin both increased pituitary GH secretion. This stimulation by cholera toxin was inhibited completely by 2-TCA. Doses of cholera toxin that stimulated GH re lease also increased tissue cyclic-AMP concentrations. Theophylline at increasing concentrations was found to have an inhibitory effect on GH secretion. These results support the concept that elevations in pituitary cyclic-AMP are associated with increased release of GH.|
|Pages/Duration:||v, 51 pages|
|Rights:||All UHM Honors Projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.|
|Appears in Collections:||Honors Projects for Biology|
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