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The Effect Of Chloroquine And Pyrimethamine On The Growth Of Two Strains Of The Human Malaria Parasite, Plasmodium Falciparum, After Long-Term Continuous In Vitro Cultivation
|Title:||The Effect Of Chloroquine And Pyrimethamine On The Growth Of Two Strains Of The Human Malaria Parasite, Plasmodium Falciparum, After Long-Term Continuous In Vitro Cultivation|
|Contributors:||Siddiqui, Wasim (advisor)|
|Date Issued:||15 Jan 2014|
|Publisher:||University of Hawaii at Manoa|
|Abstract:||Two strains of the human malaria parasite, Plasmodium falciparum, were maintained in Aotus trivirgatus by serial passages, subsequently cultured continuously·in-vitro, and then tested to determine their susceptibility to two antimalarial drugs, chloroquine and pyrimethamine. The Uganda-Palo Alto (FUP) strain, susceptible to chloroquine and resistant to pyrimethamine when maintained in-vivo, was found to be more susceptible to chloroquine and susceptible to pyrimethamine after continuous in-vitro cultivation for 652 days. The Vietnam-Oak Knoll (FVO) strain, resistant to chloroquine and susceptible to pyrimethamine when maintained in-vivo, was found to be susceptible to chloroquine and more susceptible to pyrimethamine after continuous in-vitro cultivation for 297 days. It was also found that after continuous in-vitro cultivation, the FUP and FVO strains showed similar sensitivities to comparable concentrations of both chloroquine and pyrimethamine, whereas prior to long term in-vitro cultivation, their responses to these two drugs were distinct.|
|Rights:||All UHM Honors Projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.|
|Appears in Collections:||
Honors Projects for Biology|
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