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Analysis of fli-I Function and Effects on Cell Morphology by Ectopic Expression

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Title:Analysis of fli-I Function and Effects on Cell Morphology by Ectopic Expression
Authors:Reed, Graeme
Contributors:Biology (department)
Date Issued:15 Jan 2014
Publisher:University of Hawaii at Manoa
Abstract:The various cellular functions of actin are facilitated by a number of proteins that associate with actin and affect the stability of the filaments. One of the genes that have been identified as being involved in actinorganizing activity in humansis FLI. The Human FLI protein and the Drosophila melanogaster homologue Fli-1 are both comprised of two domains, a gelsolin like domain, GLD with its 6 fold segmental repeats, and an amino-terminal extension of 16 tandem leucine rich repeats, LRR. This study uses the Gal4/UAS system to induce ectopic expression of theFli-1 gene and each of its two domains and examines the manner in which these domains work to control the assembly of actin filaments in the sensory cells in the Drosophila compound eye.
Pages/Duration:32 pages
Rights:All UHM Honors Projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Appears in Collections: Honors Projects for Biology

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