Analysis of fli-I Function and Effects on Cell Morphology by Ectopic Expression

Date
2014-01-15
Authors
Reed, Graeme
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University of Hawaii at Manoa
Abstract
The various cellular functions of actin are facilitated by a number of proteins that associate with actin and affect the stability of the filaments. One of the genes that have been identified as being involved in actinorganizing activity in humansis FLI. The Human FLI protein and the Drosophila melanogaster homologue Fli-1 are both comprised of two domains, a gelsolin like domain, GLD with its 6 fold segmental repeats, and an amino-terminal extension of 16 tandem leucine rich repeats, LRR. This study uses the Gal4/UAS system to induce ectopic expression of theFli-1 gene and each of its two domains and examines the manner in which these domains work to control the assembly of actin filaments in the sensory cells in the Drosophila compound eye.
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