Effects of Diphenylamine (DPA) on Na+ and Water Movement in the Toad

Abstract

Diphenylamine (DPA) (C6H5)2NH prepared with a wetting agent was shown to be effective in the control of storage scald in apples. It is effective in controlling screw worm infection in cattle and functions as an anti-oxidant in the preservation of carotene in alfalfa. Studies of the long term effects of DPA ingestion by rats showed the development of kidney cysts morphologically similar to human polycystic disease. Further investigation of DPA induced cystic changes in rats made by Kime et al. (1962) showed changes in renal tubules varying from tubular dilation to overt cyst formation.