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Insights into the Mechanistic Basis of the Irukandji Syndrome by evaluating the Hematologic and Immunologic Responses in Whole Blood
|Lee_Amanda_Mechanistic Basis of Irukandji Syndrome.pdf||13.87 MB||Adobe PDF||View/Open|
|Title:||Insights into the Mechanistic Basis of the Irukandji Syndrome by evaluating the Hematologic and Immunologic Responses in Whole Blood|
|Issue Date:||25 Apr 2011|
|Publisher:||University of Hawaii at Manoa|
|Abstract:||The Hawaiian Box jellyfish, Alatina mordens (previously classified as Carybdea alata), aggregates on certain lee shores of Oahu 7-10 days after each full moon. This animal's appearance and the composition of its venom present areas of interest for the tourism industry and local beachgoers because of the painful stings they inflict. This stinging capability is mediated by potent venom, which contains pore-forming proteins (porins) that are introduced into the blood stream of the sting victim through thousands of stinging cell tubules that pierce the skin tissue. We have shown that venom porins assemble to create large pores in the membrane of the blood cells and cause the release of molecules from the cell. We hypothesize that host molecules released from cells may account for a variety of symptoms that include, the life threatening, Irukandji syndrome.|
|Rights:||All UHM Honors Projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.|
|Appears in Collections:||Honors Projects for Microbiology|
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