Deconvolution of light scattering and diffuse reflectance signatures for delineation of mucosal cancer cells using wavelet analysis
Deconvolution of light scattering and diffuse reflectance signatures for delineation of mucosal cancer cells using wavelet analysis
Date
2005
Authors
Hernandez, Luis Manuel Ortiz
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Abstract
This thesis presents a technique to measure cells using a Fabry-Perot optical model along with wavelet decomposition applied to the reflected or transmitted optical spectrum. Cell size measurement is used as an indicator in early diagnosis of cancer. This research is based on developing a non-invasive, optical system to detect dysplasia in mucosal tissues; this is achieved by analysis of the reflectance or transmittance spectrum to determine the mutated cells' sizes. The collected spectrum contains information about the cell's internal structure. To decode this information, an optical cell model was formulated to create a custom mother wavelet to be used to deconvolve the absorption and light scattering components of the collected spectra. Finally, the previous results are fitted to different models for prediction, of cell sizes and the results with the least error are presented as a Gaussian distribution.
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Thesis (M.S.)--University of Hawaii at Manoa, 2005.
Includes bibliographical references (leaves 71-72).
xii, 89 leaves, bound ill. 29 cm
Includes bibliographical references (leaves 71-72).
xii, 89 leaves, bound ill. 29 cm
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Cancer -- Diagnosis -- Equipment and supplies,
Mucous membrane -- Cancer
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Theses for the degree of Master of Science (University of Hawaii at Manoa). Electrical Engineering; no. 4036
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