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Symbiont-induced changes in host gene expression: The squid-Vibrio symbiosis

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Title:Symbiont-induced changes in host gene expression: The squid-Vibrio symbiosis
Authors:Kimbell, Jennifer Loraine
Contributors:McFall-Ngai, Margaret (advisor)
Biomedical Sciences (Cellular & Molecular Biology) (department)
Keywords:Host gene expression
Vibrio fischeri
Euprymna scolopes
Light organs
show 2 moreCellular biology
Molecular biology
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Date Issued:Dec 2003
Publisher:University of Hawaii at Manoa
Citation:Kimbell, Jennifer Loraine (2003) Symbiont-induced changes in host gene expression: The squid-Vibrio symbiosis. Ph.D. dissertation, University of Hawai'i, United States -- Hawaii.
Abstract:All animals exist in lifelong relations with a complement of bacteria. Because of the ubiquity of these symbioses as well as the derived biomedical applications, the study of both beneficial and pathogenic host-microbe associations has long been established. The monospecific light organ association between the Hawaiian sepiolid squid Euprymnascolopes and the marine luminous bacterium Vibrio fischeri has been used as a experimental model for the study of the most common type of animal-bacterial interaction, i.e., the association of coevolved Gram-negative bacteria with the extracellular apical surfaces of polarized epithelia. A fundamental step for understanding the mechanisms of host-symbiont associations lies in defining the genetic components involved; specifically defining changes in host gene expression. The studies presented in this dissertation identify and characterize V. fischeri-induced changes in host gene expression at both the transcript and protein level.
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Appears in Collections: Ph.D. - Biomedical Sciences (Cell & Molecular Biology)

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