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Investigation of manganese binding potential in neoplastic and non-neoplastic tissue

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Item Summary

Title:Investigation of manganese binding potential in neoplastic and non-neoplastic tissue
Authors:Zimmerman, Norman
Date Issued:1971
Abstract:In an attempt to discover methods of controlling cancer, two basic philosophies of research prevail. The first involves testing vast multitudes of drugs in the hope that one may be found which destroys the malignancy without killing the patient. The second espouses the finding of differences between neoplastic and non-neoplastic tissue in the hope that these differences may elucidate the nature of the carcinogenic process. Once this is known, one would hope to be able, teleologically, to select possible methods of cure. Clearly, a great number of differences between neoplastic tissue and the tissue of origin of the neoplasm simply reflect cellular differences and in no way relate to the carcinogenic process. The dissertation will be concerned with the differences in manganese binding potential in neoplastic and non-neoplastic tissue that has been observed by the use of Electron Paramagnetic Resonance (EPR). A general discussion of EPR and the role of manganese in normal tissue will be followed by a proposed theory of carcinogenesis. Evidence will then be presented for differences in manganese binding potential between neoplastic tissue and the tissue of origin for six different systems. Competition studies will be utilized to show that the effect observed with manganese cannot be seen for a variety of other ions (i.e., it is not a common ion effect). A brief discussion on endogenous manganese levels will be included. A discussion of purification of the binding system will follow. In conclusion, data will be presented regarding manganese binding potential with respect to the carcinogenic process.
Thesis (Ph. D.)--University of Hawaii, 1971.
Bibliography: leaves 132-136.
x, 136 l graphs, tables
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Appears in Collections: Ph.D. - Biomedical Sciences (Biochemistry)

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