Please use this identifier to cite or link to this item: http://hdl.handle.net/10125/101420

Stereochemistry of gamma-amino-beta-hydroxy acids of natural and synthetic origin

File Description Size Format  
Preciado Alejandro r.pdf Version for non-UH users. Copying/Printing is not permitted 5.78 MB Adobe PDF View/Open
Preciado Alejandro uh.pdf Version for UH users 6.1 MB Adobe PDF View/Open

Item Summary

dc.contributor.author Preciado, Alejandro Benito
dc.date.accessioned 2016-02-19T22:09:41Z
dc.date.available 2016-02-19T22:09:41Z
dc.date.issued 2012-05
dc.identifier.uri http://hdl.handle.net/10125/101420
dc.description Ph.D. University of Hawaii at Manoa 2012.
dc.description Includes bibliographical references.
dc.description.abstract The following dissertation will discuss my contribution to research in the area of structure elucidation, specifically dealing with the configurational assignment of γ-amino-β-hydroxy acid derivatives. Our investigations have unveiled a simple 1H NMR methodology useful for assigning the relative configuration of the intact moiety. In an effort to validate a general method for the complete configurational assignment of statine derivatives, we have performed an extensive time course study on the hydrolysis rates of the statine derivatives. These investigations have led us to propose a reliable, general and optimal approach for complete configurational assignment of the most common naturally occurring statine derivatives. Finally, a total synthesis of the stictamide A and B and evaluation of biological activities are presented. The synthesis of these natural products provides evidence to support of the originally proposed structures and expands the scope of the 1H NMR methodology useful for assigning the configuration of statine derivatives.
dc.language.iso eng
dc.publisher [Honolulu] : [University of Hawaii at Manoa], [May 2012]
dc.relation Theses for the degree of Doctor of Philosophy (University of Hawaii at Manoa). Chemistry.
dc.subject structure elucidation
dc.subject gamma-amino-beta-hydroxy acids
dc.title Stereochemistry of gamma-amino-beta-hydroxy acids of natural and synthetic origin
dc.type Thesis
dc.type.dcmi Text
Appears in Collections: Ph.D. - Chemistry


Please email libraryada-l@lists.hawaii.edu if you need this content in ADA-compliant format.

Items in ScholarSpace are protected by copyright, with all rights reserved, unless otherwise indicated.