Please use this identifier to cite or link to this item: http://hdl.handle.net/10125/101419

Psycho-social phenotype and brain n-sulfated heparan sulfates in MeCP2 mutant mice

File Description Size Format  
Pearson_Brandon_r.pdf Version for non-UH users. Copying/Printing is not permitted 4.92 MB Adobe PDF View/Open
Pearson_Brandon_uh.pdf Version for UH users 5.1 MB Adobe PDF View/Open

Item Summary

Title:Psycho-social phenotype and brain n-sulfated heparan sulfates in MeCP2 mutant mice
Authors:Pearson, Brandon
Keywords:psycho-social phenotype
autism models
MeCP2
Date Issued:May 2012
Publisher:[Honolulu] : [University of Hawaii at Manoa], [May 2012]
Abstract:A variety of inbred and mutant strains of mice exhibit impairments in social behaviors and restricted, repetitive behaviors; these constitute face validity for autism models. However, researchers rarely evaluate the psychological state eliciting the impaired social investigation and there remain no reliable biomarkers for autism. A series of studies was conducted to assess social behavior in methyl CpG binding protein 2 (MeCP2308/Y) mutant mice, which were subsequently shown to be hypersocial. Analyses of psychostimulant-based behavioral responses were assessed in the hypersocial MeCP2 mutant mice and in hypo-social BTBR T+tf/J mice relative to their respective controls. This body of work suggests that dysregulated reward processing in candidate mutant mice, and specifically, MeCP2 hypomorphs, may underlie inflexible and abnormal social behaviors. N-sulfated heparan sulfate alterations in the brain may underlie brain developmental and behavioral abnormalities in autism. To ascertain whether MeCP2 mutation influences heparan sulfate proteoglycan systems, fluorescence immunohistochemistry was performed on wild-type and mutant mouse brains throughout the neurogenic lateral ventricle subventricular zone and it was shown that, counter to the prediction, MeCP2308/Y mutants display normal levels of heparan sulfate and laminin extracellular matrix markers in the neurogenic subventricular zone. Perhaps other brain regions or alternative markers should be included in future analyses; yet, the overall influence of adult neurogenesis and other brain plasticity processes in autism-relevant behavior deficits has not been fully characterized. This body of work utilizes multiple levels of analyses in an attempt to elucidate neurobiological and psychological contributions to abnormal and autism-relevant behavioral disturbances.
Description:Ph.D. University of Hawaii at Manoa 2012.
Includes bibliographical references.
URI/DOI:http://hdl.handle.net/10125/101419
Appears in Collections: Ph.D. - Psychology


Please email libraryada-l@lists.hawaii.edu if you need this content in ADA-compliant format.

Items in ScholarSpace are protected by copyright, with all rights reserved, unless otherwise indicated.