Please use this identifier to cite or link to this item: http://hdl.handle.net/10125/100875

Systemic mitochondrial function, type 2 diabetes, obesity, and life-style modifications

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Item Summary

Title:Systemic mitochondrial function, type 2 diabetes, obesity, and life-style modifications
Authors:Juan, Jemily Gamiao
Keywords:mitochondrial dysfunction
T2DM
Date Issued:Dec 2012
Publisher:[Honolulu] : [University of Hawaii at Manoa], [December 2012]
Abstract:Mitochondrial (mt) dysfunction is emerging as a key factor of T2DM. We hypothesize that systemic mt function in PBMCs is altered in the presence of T2DM and obesity, and can be improved with life-style modifications, regardless of T2DM and obesity status.
In a cross-sectional study (N = 84), PBMC mtDNA levels and OXPHOS Complex I protein levels are increased in the presence of obesity and decreased in the presence of T2DM. Mt parameters correlated with clinical and metabolic measurements. In a longitudinal study, systemic mt function is increased in PBMCs due to life-style modifications, regardless of T2DM status. Findings in our investigations show that systemic mt function in PBMCs is altered in the presence of T2DM and/or obesity and can be improved with life-style modifications. Our study suggests that altered mt function in PBMCs is associated with T2DM and obesity, and can be improved through life-style modifications.
Description:M.S. University of Hawaii at Manoa 2012.
Includes bibliographical references.
URI/DOI:http://hdl.handle.net/10125/100875
Appears in Collections: M.S. - Molecular Biosciences and Bioengineering


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