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Systemic mitochondrial function, type 2 diabetes, obesity, and life-style modifications
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|Title:||Systemic mitochondrial function, type 2 diabetes, obesity, and life-style modifications|
|Authors:||Juan, Jemily Gamiao|
|Issue Date:||Dec 2012|
|Publisher:||[Honolulu] : [University of Hawaii at Manoa], [December 2012]|
|Abstract:||Mitochondrial (mt) dysfunction is emerging as a key factor of T2DM. We hypothesize that systemic mt function in PBMCs is altered in the presence of T2DM and obesity, and can be improved with life-style modifications, regardless of T2DM and obesity status.|
In a cross-sectional study (N = 84), PBMC mtDNA levels and OXPHOS Complex I protein levels are increased in the presence of obesity and decreased in the presence of T2DM. Mt parameters correlated with clinical and metabolic measurements. In a longitudinal study, systemic mt function is increased in PBMCs due to life-style modifications, regardless of T2DM status. Findings in our investigations show that systemic mt function in PBMCs is altered in the presence of T2DM and/or obesity and can be improved with life-style modifications. Our study suggests that altered mt function in PBMCs is associated with T2DM and obesity, and can be improved through life-style modifications.
|Description:||M.S. University of Hawaii at Manoa 2012.|
Includes bibliographical references.
|Appears in Collections:||M.S. - Molecular Biosciences and Bioengineering|
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