Please use this identifier to cite or link to this item: http://hdl.handle.net/10125/100649

Dose-dependent functions of FGF9 in male primordial germ cell differentiation

File Description Size Format  
Ulu Ferhat r.pdf Version for non-UH users. Copying/Printing is not permitted 1.6 MB Adobe PDF View/Open
Ulu Ferhat uh.pdf Version for UH users 1.63 MB Adobe PDF View/Open

Item Summary

Title:Dose-dependent functions of FGF9 in male primordial germ cell differentiation
Authors:Ulu, Ferhat
Keywords:Fibroblast Growth Factor 9
Date Issued:Aug 2013
Publisher:[Honolulu] : [University of Hawaii at Manoa], [August 2013]
Abstract:Primordial Germ Cells (PGCs) are the precursors of gametes. For PGC male differentiation, (i) inhibition of meiosis and (ii) male-inducing factor(s) are essential. It was recently revealed that Fibroblast Growth Factor 9 (FGF9) is one of male-inducing factors. Using isolated PGC culture system, we examined the function of FGF9 in PGC differentiation. We found low FGF9 treatment (0.2 ng/ml) induced PGC male differentiation. Conversely, high FGF9 treatment drastically stimulated PGC proliferation (40%) compared with the control and low FGF9 groups (5~10%). As a result, high FGF9 treatment (25 ng/ml) prevented PGCs to enter the male pathway. Also, we demonstrated that high FGF9 induced ERK1/2 signaling activation for stimulating PGC proliferation while low FGF9 enhanced phosphorylation of p38 signaling to push PGCs into the male pathway.
Description:M.S. University of Hawaii at Manoa 2013.
Includes bibliographical references.
URI:http://hdl.handle.net/10125/100649
Appears in Collections: M.S. - Developmental and Reproductive Biology


Please email libraryada-l@lists.hawaii.edu if you need this content in ADA-compliant format.

Items in ScholarSpace are protected by copyright, with all rights reserved, unless otherwise indicated.