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Dose-dependent functions of FGF9 in male primordial germ cell differentiation

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Item Summary

Title:Dose-dependent functions of FGF9 in male primordial germ cell differentiation
Authors:Ulu, Ferhat
Keywords:Fibroblast Growth Factor 9
Date Issued:Aug 2013
Publisher:[Honolulu] : [University of Hawaii at Manoa], [August 2013]
Abstract:Primordial Germ Cells (PGCs) are the precursors of gametes. For PGC male differentiation, (i) inhibition of meiosis and (ii) male-inducing factor(s) are essential. It was recently revealed that Fibroblast Growth Factor 9 (FGF9) is one of male-inducing factors. Using isolated PGC culture system, we examined the function of FGF9 in PGC differentiation. We found low FGF9 treatment (0.2 ng/ml) induced PGC male differentiation. Conversely, high FGF9 treatment drastically stimulated PGC proliferation (40%) compared with the control and low FGF9 groups (5~10%). As a result, high FGF9 treatment (25 ng/ml) prevented PGCs to enter the male pathway. Also, we demonstrated that high FGF9 induced ERK1/2 signaling activation for stimulating PGC proliferation while low FGF9 enhanced phosphorylation of p38 signaling to push PGCs into the male pathway.
Description:M.S. University of Hawaii at Manoa 2013.
Includes bibliographical references.
Appears in Collections: M.S. - Developmental and Reproductive Biology

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