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One, Two, Structure of tubercidin-5'-a-glucopyranose

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Item Summary

Title: One, Two, Structure of tubercidin-5'-a-glucopyranose
Structure of tubercidin-5'-a-glucopyranose
Structures of nostocyclophanes A-D
Determination of the total structures of puwainaphycins A-E
Biosynthetic studies of microcystin-LR
Authors: Chen, Jian-Lu
Issue Date: 1991
Abstract: Tubercidin-5'-α-D-glucopyranose is the major cytotoxic and fungicidal nucleoside in Tofypothrix distorta (BL-11-2). Its structure was elucidated by spectral analysis and enzymatic degradation to tubercidin, which was first isolated from Streptomyces tubercidicus, and D-glucose. Nostocyclophanes A-D are the cytotoxins associated with the blue-green alga Nostoc linckia (Roth) Bornet ex Bornet & Flahault (UTEX B1932). The gross structures of these [7.7]paracyclophanes have been elucidated by mass and NMR spectral analyses and the relative and absolute stereochemistry of nostocyclophane 0 determined by X-ray crystallography. Since the CD spectra of the four compounds are essentially identical, nostocyclophanes A-D are proposed to have the same stereochemistry. The sugar unit in nostocyclophane A and B has been shown to be D-glucose by semisynthesis of nostocyclophane B heptaacetate from nostocyclophanes B and D.
Description: Thesis (Ph. D.)--University of Hawaii at Manoa, 1991.
Includes bibliographical references.
xvii, 160 leaves, bound ill. 29 cm
Rights: All UHM dissertations and theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Appears in Collections:Ph.D. - Chemistry

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