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One, Two, Structure of tubercidin-5'-a-glucopyranose
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|Title:||One, Two, Structure of tubercidin-5'-a-glucopyranose|
Structure of tubercidin-5'-a-glucopyranose
Structures of nostocyclophanes A-D
Determination of the total structures of puwainaphycins A-E
Biosynthetic studies of microcystin-LR
|Abstract:||Tubercidin-5'-α-D-glucopyranose is the major cytotoxic and fungicidal nucleoside in Tofypothrix distorta (BL-11-2). Its structure was elucidated by spectral analysis and enzymatic degradation to tubercidin, which was first isolated from Streptomyces tubercidicus, and D-glucose. Nostocyclophanes A-D are the cytotoxins associated with the blue-green alga Nostoc linckia (Roth) Bornet ex Bornet & Flahault (UTEX B1932). The gross structures of these [7.7]paracyclophanes have been elucidated by mass and NMR spectral analyses and the relative and absolute stereochemistry of nostocyclophane 0 determined by X-ray crystallography. Since the CD spectra of the four compounds are essentially identical, nostocyclophanes A-D are proposed to have the same stereochemistry. The sugar unit in nostocyclophane A and B has been shown to be D-glucose by semisynthesis of nostocyclophane B heptaacetate from nostocyclophanes B and D.|
|Description:||Thesis (Ph. D.)--University of Hawaii at Manoa, 1991.|
Includes bibliographical references.
xvii, 160 leaves, bound ill. 29 cm
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|Appears in Collections:||Ph.D. - Chemistry|
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