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A nested case-control study of dietary and serum antioxidant exposures and the risk of developing Parkinson's disease
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|Title:||A nested case-control study of dietary and serum antioxidant exposures and the risk of developing Parkinson's disease|
|Abstract:||Free radical oxidation may be involved in the etiology of idiopathic Parkinson's disease (IPD).A nested case-control study of the association of IPO with serum and dietary antioxidants was conducted in the Honolulu Heart Program (ID-IP) cohort of 8,006Japanese men. Eighty-four definite IPO cases occurring in the HHP cohort were verified by autopsy, record review, or direct neurological examination, and age-matched with 336 controls. Dietary and serum antioxidant data for this study were obtained from the first HHP cohort examination (Exam I) in 1965-1968. Conditional logistic regression was used to estimate odds ratios (ORs) for each variable, and as a test of trend for ordinal data and continuous data collapsed into quartiles. The adjusted odds ratio (aOR) relating IPO occurrence to vitamin E intake greater than the Recommended Dietary Allowance (RDA)was not significant (aOR=O.64, 95 percent a 0.35-1.17). The test for trend was also not significant. Intakes of several foods with high vitamin E content identified in a 24 hour dietary recall in 196>1968 were inversely associated with IPD occurrence, but only legume consumption was significantly associated (aOR =0.27, 95 percent CI 0.09-0.78). IPD occurrence was, however, associated with vitamin C intake above the RDA (OR =1.74,95 percent a 1.07-2.85). The association was attenuated by adjustment for smoking and coffee drinking (aOR =1.51, 95 percent a 0.90-2.52), and the test for trend was also not significant after adjustment for smoking and coffee drinking. IPD was also inversely associated with consumption of a western diet (aOR =0.6095 percent a 0.35-1.01) when compared with a Japanese diet, but no significant trend was detected after adjustment for smoking and coffee drinking. IPD was also associated with serum. uric acid (VA) concentration (aOR = 0.82, 95 percent a 0.69-0.99). The odds ratio for VA above the median (OR=O.60, 95 percent a 0.37-0.97) was only slightly attenuated after adjustment for smoking history and coffee consumption (aOR = 0.66, 95 percent a 0.41-1.08). IPD may be associated with prior dietary factors, but the relationship may be complex and difficult to measure retrospectively using epidemiologic techniques.|
|Description:||Thesis (Ph. D.)--University of Hawaii at Manoa, 1994.|
Includes bibliographical references (leaves 89-106).
xi, 106 leaves, bound ill. 29 cm
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|Appears in Collections:||Ph.D. - Biomedical Sciences (Biostatistics - Epidemiology)|
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