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The Effects of Prolonged Cold Storage on the Activity of Isolated Rabbit Atrium

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Title: The Effects of Prolonged Cold Storage on the Activity of Isolated Rabbit Atrium
Authors: Timmerman, Donald
Advisor: Shibata, Shoji
Issue Date: 15 Jan 2014
Publisher: University of Hawaii at Manoa
Abstract: This laboratory has recently become interested in the use of hypothermia as a physiological and pharmacological tool. This interest springs from Dr. Shibata's unique observation that cold-storage modifies the responsiveness of vascular smooth muscle to certain drugs (1). Dr. Shibata's subsequent research has provided evidence for differential effects of cold storage on the autonomic nervous system in isolated perfused tissue (2, 3). At a recent FASEB meeting in Atlantic City, this laboratory presented evidence supporting the theory that with prolonged cold storage there is a depletion of tissue stores of catecholamines. In view of these and other unpublished results, it was decided to study the effect of hypothermia on the isolated rabbit myocardium.
Pages/Duration: 44 pages
URI/DOI: http://hdl.handle.net/10125/32055
Rights: All UHM Honors Projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission from the copyright owner.
Appears in Collections:Honors Projects for Biology



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